Award-winning plant exosome skincare active ingredient powered by pomegranate exosomes - Naolys

From Correction to Adaptation

Aethelis Granata is the first cosmetic active born from Naolys’ proprietary ExoCell® plant exosome technology, combining plant intelligence, epigenetic science, and a novel well-aging approach.

Rather than focusing solely on correcting visible signs of ageing, Aethelis Granata targets SUMOylation, an adaptive cellular mechanism involved in chromatin organisation, DNA repair and cellular resilience.

By leveraging plant exosomes as biological messengers, Aethelis Granata supports cellular adaptation mechanisms associated with skin longevity, resilience and healthy aging.

Award-winning biotech active

In 2026, Aethelis Granata received two major international distinctions recognizing its innovative epigenetic well-ageing approach:

Cosmetics & Toiletries Allē Awards 2026

1st Place Cosmetic Active Anti-Aging category

BSB Awards 2026

1st Place Raw Materials Active Skin Rejuvenation & Well-Aging category

Developed with ExoCell® technology

ExoCell® is Naolys’ proprietary plant exosome technology platform, developed to create a new generation of cosmetic actives derived from Naolys’ patented plant cell culture.

Aethelis Granata is the first cosmetic actives developed through the ExoCell® platform, combining plant intelligence, epigenetic science, and well-aging innovation.

ExoCell® also opens the door to tailor-made plant exosome developments designed around your own skincare vision.

“Plants have spent millions of years developing extraordinary survival and adaptation mechanisms. With Aethelis Granata, we sought to translate this living intelligence into a new cosmetic language dedicated to skin longevity and well-aging.“

The future of well-aging driven by plant exosomes

A remarkable clinical performance versus placebo

Clinical results demonstrated that targeting adaptive epigenetic pathways can translate into visible wrinkle reduction.

Aethelis Granata delivered one of the most visually significant wrinkle improvements observed in our anti-aging portfolio versus placebo, demonstrating fast and measurable efficacy after only 28 days at 0.5%, alongside long-lasting hydration benefits visible after just one application.

Beyond instrumental measurements, participants also reported visibly healthier-looking skin, and highlighted the perceptible rejuvenating effect of the formula.

-27%

wrinkle length

-22%

total wrinkle surface area

-19%

wrinkle number

-9%

wrinkle depth

+40%

hydration after 2 hours

+79%

hydration after 8 hours

Additional in vitro studies demonstrated stimulation of key cellular pathways involved in skin vitality such as mitochondrial biogenesis.

Unique epigenetic approach

SUMOylation at the heart of a new well-ageing strategy

Aethelis Granata works through an innovative epigenetic approach centered on SUMOylation, a biological regulation mechanism involved in cellular adaptation, mitochondrial function, and protein organization.

SUMOylation is a complex post-translational modification of proteins

A highly differentiated scientific territory in cosmetic biotechnology

A new vision of advanced well-aging

Moves beyond traditional anti-aging claims toward:

1

skin longevity

2

resilience

3

adaptive biology

4

cellular communication

5

skin vitality

A new generation of biotech active powered by plant exosomes

In 2003, Naolys became the very first company worldwide to launch cosmetic actives derived from plant cell culture, pioneering a new generation of sustainable and high-performance cosmetic ingredients.

Developed using Naolys’ patented plant cell culture biotechnology, Aethelis Granata embodies more than 20 years of expertise in advanced botanical biotechnology.

Aethelis Granata

Well-ageing beauty activated by epigenetics

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Frequently Asked Questions

What makes Aethelis Granata different from traditional anti-aging actives?

Aethelis Granata introduces an innovative epigenetic approach centered on SUMOylation pathways and adaptive cellular responses, promoting skin resilience, cellular communication and biomimetic regeneration for advanced well-aging and skin longevity.

Is Aethelis Granata sustainable?

Yes. Aethelis Granata is developed using Naolys’ patented plant cell culture biotechnology, designed to reduce pressure on natural resources while ensuring traceability, scalability and sustainable production.

Why pomegranate?

Pomegranate is a powerful symbol of vitality and resilience. Naturally resistant to drought and environmental stress, it inspired the biomimetic philosophy behind Aethelis Granata: “From plant resilience to skin resilience.”

What are plant exosomes?

Plant exosomes are nano-sized biological vesicles naturally released by plant cells. They transport bioactive signals involved in cellular communication and adaptive biological mechanisms. In cosmetics, they open new biomimetic perspectives for supporting skin vitality and resilience.

What is SUMOylation?

SUMOylation is a natural cellular regulation mechanism involved in chromatin organization, mitochondrial function, adaptive cellular pathways, cellular communication and DNA damage response mechanisms.

What is ExoCell®?

ExoCell® is Naolys’ proprietary plant exosome technology platform developed from patented plant cell culture biotechnology. It explores the cosmetic potential of plant-derived exosomes for advanced biomimetic skincare applications.

Can ExoCell® be customized?

Yes. ExoCell® also opens the door to tailor-made plant exosome developments designed around your own skincare vision. Naolys can support custom exosome developments adapted to specific cosmetic applications and botanical targets.

Since when has Naolys worked on plant biotechnology?

Naolys has specialized in plant cell culture biotechnology for more than 20 years and was the first company worldwide to launch cosmetic actives derived from plant cell culture in 2003.

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Aethelis
Granata

Award-winning biotech innovation

with a new SUMOylation-driven approach to well-ageing, shifting skin care from correction to adaptation.