Calendula, also known as pot marigold, is a herbaceous plant recognized for both its beauty and beneficial properties. Native to the Mediterranean region, Calendula is admired for its magnificent golden petals, radiating like a miniature sun. Belonging to the Asteraceae family, this plant has been cherished for centuries for its medicinal and cosmetic uses. Calendula’s botanical DNA is rich in beneficial compounds such as flavonoids, carotenoids, and phenolic acids, providing the plant cells with anti-inflammatory, soothing, and regenerative properties.
Beyond its floral beauty, Calendula embodies botanical richness, offering invaluable potential to nourish and care for the skin, making it an exceptional ally in the world of natural cosmetics.
In the intricate dance of the skin’s biology, the recognition of the cellular level as the primary battleground for skin ageing is pivotal.
The stimulation of the inner skin structures becomes a proactive response, a commitment to fortifying the skin’s foundation at both dermal and epidermal levels. It’s an ode to the skin’s resilience and an acknowledgement that a well-nurtured cellular framework is an investment for ageless vitality and a radiant complexion.
COMBATTING OXIDIZED PROTEINS
Antioxidant effect, cellular preservation.
REGENERATION
Deep cell regeneration.
ANTI-INFLAMMATION
Calming redness, irritation, and discomfort.
SKIN COHESION
Preventing and maintaining optimal skin barrier structure.
REMODELLING OF THE EXTRACELLULAR MATRIX
The skin's ability to remodel and adapt to ageing.
LOWERING SENESCENT CELLS
A significant reduction in the presence of senescent cells.
• INCI name of the Active plant cells: Calendula Officinalis Callus Extract*
*Submitted to PCPC
• Forms: Liquids: soluble cells (20%) in glycerin or sunflower oil (80%) / Powder : dispersible cells (100%)
• Concentration: starting at 0.5%
• Suitable for all types of formulation
Exposure to harsh weather conditions, such as extreme temperatures, strong winds, or low humidity, can strip the skin of its natural moisture, leading to dehydration. Prolonged exposure to pollution, including airborne particles and environmental toxins, can contribute to oxidative stress—a process wherein free radicals damage skin cells and accelerate ageing. UV radiation from the sun is a major environmental factor that not only causes sunburn but also triggers inflammation and can lead to long-term skin damage, including the development of fine lines, wrinkles, and pigmentation issues.
These external stressors compromise the skin’s natural defences and underscore the necessity of regenerating essential components like ceramides, collagens, elastin, and glycosaminoglycans (GAGs) for optimal skin health.
Considering the myriad factors at play within the skin, including endogenous elements such as genetic predispositions, hormonal fluctuations, and metabolic processes, the dynamic interplay of these endogenous factors, coupled with external stressors, underscores the complexity of skin health.
Diagram
intervening in epidermal differentiation, regulating inflammation, and restoring skin lipids. Establishing harmony between external and internal factors for fully optimized skin.
specifically targets oxidation-sensitive proteins and senescent cells, stimulating the production of essential components such as elastin, glycosaminoglycans (GAGs), collagen, and ceramides.
actively protecting against internal and external threats, minimizing water loss, promoting water retention, and reinforcing the skin’s barrier function, creating active defence.
caring for the extracellular matrix, fostering deep cell regeneration, contributing to skin resilience, elasticity, and firmness to preserve the skin’s structural integrity.
In the intricate web of cellular functions, proteins emerge as the keystones, governing diverse physiological roles— from oxygen transportby haemoglobin to the structural support provided by collagen.
Oxidized proteins disrupt crucial biological mechanisms, compromising enzymatic functions, cell signalling, and cellular structure integrity. This interference extends to immune functions, gene regulation, and stress response, impacting cellular balance and contributing to pathological conditions.
Accumulation of damaged proteins, driven by oxidation and inflammation, challenges skin health, affecting the extracellular matrix (ECM) and proteasome activity.
Enter InnerLift Calendula, as a proactive guardian against diverse protein-damaging forces. The studies evaluate the impact of InnerLift Calendula on the levels of oxidized proteins.
InnerLift Calendula demonstrates a considerable antioxidant effect, evident in the reduction of oxidized proteins, thereby safeguarding cellular components.
This impact extends to enabling the correct functioning of other mechanisms, including proteasomes.
Inflammation, a vital part of the body’s defence system, plays a pivotal role in recognizing, combating, and neutralizing threats. In terms of skincare, it often manifests as redness, irritation, and discomfort.
Naolys opted to investigate three inflammation mediators synthesized by keratinocytes: two cytokines and one prostaglandin, to highlight the beneficial effects of InnerLift Calendula in soothing the cellular matrix.
InnerLift Calendula demonstrates the ability to effectively inhibit irritative and inflammatory responses.
By doing so, it goes beyond mere soothing and comfort and gives the skin a healthier and more vibrant appearance.
The concept of “lift” involves enhancing skin density through epidermal regeneration, facilitated by the symbiotic relationship between the papillary dermis and the epidermis. Naolys assessed the skin’s renewal process by focusing on the nuclear protein Antigen Ki-67, a marker for cell proliferation. Active Plant Cells in InnerLift Calendula play a crucial role in repairing and renewing cells, contributing to overall regeneration and optimal skin condition.
Furthermore, InnerLift Calendula reinforces the skin barrier through the differentiation of the epidermis and promotes hydration, involving proteins like loricrin and involucrin. These proteins support keratinization and cornification processes, strengthening the skin’s barrier function and enhancing moisture retention.
Additionally, InnerLift Calendula stimulates ceramide production, essential lipid molecules for the skin barrier, ensuring a well-hydrated and resilient skin matrix.
Fibroblasts are key players in the maintenance and constant remodelling of the dynamic extracellular matrix (ECM).
Degradation is part of the dynamic remodelling process, allowing for the removal of old or damaged ECM elements and facilitating the incorporation of newly synthesized ones, a vital aspect of the healing process.
Fibroblasts can synthesize and secrete various components, such as collagen, elastin, and other structural proteins. Those key components play crucial roles and contribute to the renewal and maintenance of the ECM. Oxidation negatively impacts fibroblasts, impairing their functions and affecting the key components.
Naolys studied the key components of cultured human fibroblasts to investigate the ECM’s structure and function. With a particular focus on total collagen synthesis, degradation, and reconstruction, which enables the skin to adapt to ageing, environmental damage, and other factors.
InnerLift Calendula plays a crucial role in maintaining skin quality by boosting key ECM components. It becomes possible to effectively support skin firmness, hydration, and elasticity, enabling the skin to adapt to ageing.
The innovative multi-pronged approach of intelligent cellular stimulation, exemplified by InnerLift Calendula, not only addresses senescent and oxidized proteins, its fosters regeneration and hydration, and remodels the extracellular matrix, but also showcases potent anti-inflammatory properties.
A pivotal investment for timeless beauty and holistic skincare.
INCREASE OF SKIN MOISTURE AFTER 2 HOURS
• 100% of volunteers reported that their skin was softer
• 95% of volunteers reported that their skin was nourished
• 95% of volunteers reported that their skin was hydrated
• 90% of volunteers reported that dry areas were repaired
DECREASE OF WRINKLES AFTER 28 DAYS
• Decrease in the total wrinkle surface area of 20%
• Decrease in the total number of wrinkles of 15%
• Decrease in the total length of wrinkles of 24%
• Decrease in the depth of wrinkles of 3%
Tests were carried out for 28 days on a sample of 20 women aged 40 to 60 years old. Assessments were made by analysis of Quantirides® and Corneometer®. Application twice a day. Emulsion with 0.5% InnerLift Calendula (20% cells)
(Corneometer®)
Tests were carried out for 28 days on a sample of 20 women aged 40 to 60 years old (Quantirides®)